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What is Nattokinase?

Nattokinase is a fibrinolytic enzyme extracted from a Japanese food called natto, a cheese-like offering made from fermented soybeans. Natto is a popular dish in Japan, where it is often eaten with rice.

Nattokinase was first extracted from natto in the mid-1980s by Chicago researcher Dr. Hiroyuki Sumi, who gave the dietary supplement its name.

It is used as a tool in a healthy diet, offering support for healthy circulation.

Natto is produced through fermentation by adding the beneficial bacteria Bacillus natto to boiled soybeans. The nattokinase enzyme is produced as the bacterium acts on the soybeans.

As a fibrionolytic enzyme, nattokinase is able to dissolve fibrin, a protein that in excessive amounts can undesirably thicken blood.

Health Benefits of Nattokinase

Nattokinase is a profibrinolytic serine protease, and studies have shown it increases the clot-dissolving activities of blood.

Nattokinase is similar to plasmin, a natural enzyme that functions as a defense mechanism against blood clots.

Nattokinase works by dissolving the tiny fibers (fibrin) that form the strong mesh in blood clots. The antioxidant function is also key for eliminating free radicals, molecules that can damage cell membranes.

Nattokinase also contains Vitamin K, which is involved in the formation of calcium-binding groups in proteins, assisting in the formation of bone.

Purity and Concentration

This product is assayed to contain 20% to 25% Nattokinase. The remainder of the product is maltodextrin, a polysaccharide that is used as a food additive. It contains no other fillers, additives or anti-caking agents.

Nattokinase contains about 20,000 fibrinolytic units per gram. (This is a measure of nattokinase "activity" in breaking down fibrin, usually by the enzymatic action of plasmin.)

Suggested Use of Nattokinase

As a dietary supplement, take 100 milligrams (rounded 1/32 tsp) one to three times a day, or as directed by physician. Individual needs may vary. You can see the full bulk density/volumetric conversion chart for nattokinase here. A level 1/32 teaspoon equals 89 milligrams (mg), so a slightly rounded 1/32 tsp is about 100 mg. The suggested serving of 100 mg will provide 2000 fibrolytic units of nattokinase activity.

Potential Side Effects of Nattokinase

Do not use if you are allergic to soy, as this product is derived from a fermentation of soybeans.

Nattokinase is safe at suggested serving sizes. Use under the guidance of a health care provider, especially if you are taking anti-coagulants, aspirin, Coumadin® or other medicines or herbs that thin the blood.

Nattokinase shouldn't be used by people with bleeding disorders, by people who are taking Coumadin (warfarin), prescription vitamin K, heparin, aspirin, diuretics, ACE inhibitors, beta blockers or any other drug that influences blood clotting (unless under doctor's supervision), or if you are pregnant, may become pregnant or are nursing.

How should I store it?

You will receive a resealable bag of this powder. Store in a cool, dry area protected from light. Reseal after each use.

References & Further Research

WebMD: Vitamin K – Keeping Calcium in Your Bones and Out of Your Blood Vessels

Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase

NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-label­ing standards and health claim limits. To learn more about DSHEA, visit the FDA Web site.