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Supplement Facts Volumetrics Certificate of Analysis

What is L-Isoleucine?

L-isoleucine is an essential amino acid primarily used to boost energy, aid physical endurance and speed up recovery time after strenuous exercise.

L-isoleucine is the fourth most abundant amino acid in human skeletal muscles, comprising about 12% of all proteins in the human body. As an essential amino acid, L-isoleucine cannot be manufactured in the body and must be consumed through dietary sources or supplementation to maintain proper health.

Good sources of isoleucine include high-protein foods such as nuts, almonds, seeds, meat, cashews, eggs, fish, chicken, liver, lentils, peas, soy protein, brown rice and whole wheat bread products.

Isoleucine is highly concentrated in muscle tissue and is particularly important to serious athletes like bodybuilders and weightlifters.

Blood levels of L-isoleucine will fall significantly after strenuous exercise and will stay low until complete recovery. Supplementation with isoleucine one hour before strenuous workouts can reduce the recovery time by increasing muscle protein synthesis and counteract catabolic (breakdown) processes.

Isoleucine is used for energy within the muscle tissue. A deficiency of isoleucine manifests symptoms similar to those seen in hypoglycemic patients, and may include headaches, dizziness, fatigue, depression, confusion, and irritability.

Isoleucine in one of the three branched-chain amino acids (BCAA) and should always be taken in conjunction with the other two: leucine and valine. For every milligram of isoleucine, take two milligrams of leucine and one milligram of valine.

All three BCAAs are essential in helping encourage muscle recovery after exercise. Isoleucine in particular keeps energy levels stable by helping to regulate blood sugar.

BCAAs promote protein synthesis in muscle. They serve as important fuel sources for skeletal muscle during periods of metabolic stress. BCAAs are needed for the maintenance of muscle tissue and appear to preserve muscle stores of glycogen. BCAAs also help prevent muscle protein breakdown during exercise.

Health Benefits of L-Isoleucine

Isoleucine helps maintain healthy and optimal levels of blood sugar and energy. As an amino acid, one of the building blocks of protein, it is needed for the formation of hemoglobin.

This amino acid plays a key role in muscle recovery after exercise and in metabolism for producing energy. Isoleucine is broken down within muscle tissue to provide energy.

It is also essential for the manufacture and synthesis of body proteins and is directly involved in blood clot formation.

Isoleucine is required for nitrogen balance in adults and for the healthy, normal growth of infants.

Purity and Concentration of L-Isoleucine

This pharmaceutical grade amino acid contains no fillers, additives or anti-caking agents.

Suggested Use of L-Isoleucine

The suggested serving size for L-isoleucine is 1000 to 2000 milligrams taken orally three times daily. Some athletes use larger amounts based on individual preference or the recommendation of a professional trainer.

You can see the full bulk density/volumetric conversion chart for L-Isoleucine here. A rounded 1/4 teaspoon will provide about 1000 mg; a rounded 1/2 teaspoon will give about 2000 mg.

If you take 1000 mg of Isoleucine, simultaneously take 1000 mg valine and 2000mg leucine for your total BCAA. If you prefer, Purebulk sells BCAA powder and capsules.

Potential Side Effects of L-Isoleucine

Those with kidney or liver disease should not consume amino acids without medical advice. People with impaired liver or kidney function should not take isoleucine without first consulting a physician, as large quantities of amino acids may aggravate these conditions. This product is not recommended for women who are pregnant or nursing.

Bioavailability, Mixing and Solubility of L-Isoleucine

L-isoleucine powder is not easily soluble in water and has a bitter taste. The best way to take the supplement is mixed with a protein shake.

How should I store it?

You will receive a resealable bag of this powder. Store in a cool, dry area protected from light. Reseal after each use.

References & Further Research

Influence of ingesting a solution of branched-chain amino acids on plasma and muscle concentrations of amino acids during prolonged submaximal exercise.

Branched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise

NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-label­ing standards and health claim limits. To learn more about DSHEA, visit the FDA Web site.