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What is Inositol Hexanicotinate?

Inositol hexanicotinate, also known as inositol nicotinate, is a nutritional supplement commonly taken as a flush-free niacin (vitamin B3) analog.

This compound is inositol esterified with niacin. Niacin is an important vitamin, but is associated with what is termed a "niacin flush" because it increases blood flow in the body.

After using niacin, many users report "flushing" as vitamin B3 causes a dilation of the blood vessels. Flushing is characterized by tingling and itching sensations, skin redness or warmth, sweating, shortness of breath, increased heart rate, chills, dizziness and even fainting. Inositol hexanicotinate, on the other hand, allows for true niacin activity without niacin's characteristic flush.

Inositol, also referred to as vitamin B8, is a water-soluble fatty lipid needed for the formation and maintenance of healthy cells. Inositol helps niacin perform its functions more effectively.

The role of Niacin

Niacin is a vital, water-soluble vitamin, also known as Vitamin B3. It is also called niacin, nicotinic acid, nicotinamide and niacinamide. Niacin is one of the most stable of the B vitamins. It is resistant to the effects of heat, light, air, acid and alkali. Niacin and niacinamide are white crystalline substances soluble in both water and alcohol. They are both readily absorbed from the small intestine. Small amounts may be kept in the liver, while most of the excess is excreted in the urine.

Niacin plays a key role in clearing the body of toxic and harmful chemicals. It helps synthesize hormones in the adrenal glands and other parts of the body. Vitamin B3 is needed for the action enzymes that catalyze or speed up chemical reactions. These enzymes are responsible for generating energy in the body, breaking down dietary fats, the creation of certain hormones and cholesterol, the processing of genetic material (DNA) and the growth and maturation of the cells in the body.

Niacin needs can be met partially by incorporating high protein foods in the diet because the human body is able to convert tryptophan, an amino acid, into niacin. Niacin, through its analogs, is involved in a variety of metabolic and biological processes, including energy production, fatty acid synthesis, signal transduction, the management of gene expression and the maintenance of genomic integrity.

Benefits of Inositol Hexanicotinate (and of Niacin)

Studies on inositol hexanicotinate show it may be capable of increasing metabolism at a total intake of at least 20 milligrams daily.

Niacin in large amounts blocks the breakdown of fats, and is occasionally taken for the treatment of hyperlipidemia (under the care of a physician).

Those who consume alcohol frequently or who are on a vegetarian or vegan diet may benefit from a niacin supplement. Alcohol inhibits niacin absorption, while low-protein diets are probably niacin deficient. Symptoms of niacin deficiency include dementia, depression, canker sores, diarrhea, dizziness, halitosis, headaches, fatigue and indigestion. Additional B3 deficiency symptoms include insomnia, limb pains, loss of appetite, low blood sugar, muscular weakness, skin eruptions and inflammation. Extreme cases of deficiency can ultimately lead to the occurrence of a potentially fatal disease called pellagra. Pellagra is caused by a lack of niacin, and is characterized by diarrhea, mental disorders, depression, and skin problems.

Like inositol hexaniacinate, inositol hexanicotinate supports liver function. Inositol hexaniacinate and inositol hexanicotinate do not increase the enzymes in the liver, which can happen when using time-released niacin. Vitamin B3 analogs play key roles in energy metabolism in living organisms.

Purity and Concentration of Inositol Hexanicotinate

Purebulk's Inositol Hexanicotinate powder contains no fillers, additives or anti-caking agents.

Potential Side Effects of Inositol Hexanicotinate

Inositol Hexanicotinate seems to be safe for most people. It can cause some side effects such as stomach upset, headache, nausea, burping and hiccups. It can cause liver damage if taken in excessive amounts. Those taking prescription drugs to treat high cholesterol or elevated blood lipid levels should consult the prescribing physician before taking this product. If you have a heart condition, diabetes, kidney problems or liver disease, check with a health care provider before using inositol hexanicotinate. Use of Inositol Hexanicotinate supplementation during pregnancy or breastfeeding is not recommended.

Suggested use of Inositol Hexanicotinate

As a dietary supplement, take 850 milligrams (1/4 tsp) two to four times daily,(or as directed by physician.) Individual needs may vary. You can see the full bulk density/volumetric conversion chart for Inositol Hexanicotinate here. A serving size of 1/4 teaspoon equals 869 milligrams (mg) so take a little less than 1/4 tsp for about 850 mg.

Bioavailability, Mixing and Solubility of Inositol Hexanicotinate

This product dissolves quickly in water and has a slightly sour taste. Mix with water or juice and drink.

Niacin products work with riboflavin (vitamin B2) and pyridoxine (vitamin B6) to support the body.

How should I store it?

You will receive a resealable bag of this powder. Store in a cool, dry area protected from light. Reseal after each use.

References & Further Research

Linus Pauling Institute, Micronutrient Information Center: Niacin

National Center for Complementary and Alternative Medicine: Vitamins and Minerals

NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-label­ing standards and health claim limits. To learn more about DSHEA, visit the FDA Web site.