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What is Hyaluronic Acid (Na Hyaluronate)?

Hyaluronic acid (also called sodium hyaluronate, or HA) is a protein component of connective tissue belonging to a family of proteins known as glycosaminoglycans. The main purpose of glycosaminoglycans is to aid in the body's water maintenance, providing essential moisture for all the body processes, and for molecular transport.

Hyaluronic acid is a glycosaminoglycan whose function is to cushion and lubricate. It occurs naturally throughout the human body and is a key component of cartilage concentrated in the synovial joint fluids (where it acts as a lubricant, shock absorber, metabolic medium and filter), the heart valves, in subcutaneous (skin) tissue where it functions as a cementing agent, and the eyes (the ocular vitreous body). In its role as a cartilage component, HA is used to help cushion and lubricate joints. HA exists naturally in most living organisms (except plants) and is a universal component of the extra cellular space.

As a supplement, HA is a white, odorless powder also known as hyaluronan. The hyaluronic acid that is used by medical practitioners is taken from rooster combs or made by bacteria in the laboratory.

Hyaluronic acid plays a crucial role in maintaining and regulating moisture within the tissues and is a key factor in the movement of nutrients into the cells and the disposal of metabolic waste. Optimum levels of hyaluronic acid are of paramount importance for the health of the joints and cartilage. HA also supports the immune system by acting as an antioxidant, holding water in the body, and lubricating heart valves.

Hyaluronic acid is a special protein occurring naturally throughout the human body, and is one of the most heavily researched substances in medicine today with thousands of clinical trials mostly in the fields of orthopedics and eye surgery. Its function in the body is, among other things, to bind water and to lubricate movable parts of the body, such as joints and muscles.

Hyaluronic acid is one of the most hydrophilic molecules in nature and as such it is aptly described as "nature's moisturizer". Aside from being the normal lubricant in human joints, hyaluronic acid is a special mucopolysaccharide that affects the way the body responds to injury. Poor lubrication due to low hyaluronic acid (HA) levels is the leading cause of painful joints.

Under sheer stress (surface gliding against surface), the viscous properties of the HA molecules in the synovial fluid act as a lubricant, protecting adjacent joint surfaces from mechanical damage. Under load bearing stress the elastic properties of HA in synovial fluid acts as a shock absorber, protecting the cartilage from compressive trauma. HA assists in managing cell migration which protect cells and also activates the white cells.

Benefits of Hyaluronic Acid

Hyaluronic acid can be taken internally as a nutritional supplement for joint health or topically as a skin moisturizer. In topical applications, hyaluronic acid may help to maintain smooth, elastic skin, and it is used in many cosmetics such as make-up and moisturizing creams. Basically, HA helps to keep water in the skin.

Hyaluronic Acid Purity and Concentration

This food grade hyaluronic acid white powder does not contain any fillers, additives or anti-caking agents. This pure product is assayed by the manufacturer to contain at least 43% of one of the active components, glucuronic acid. Keep the powder in a cool, dry, dark place for storage. Reseal after each use.

Potential Side Effects of Hyaluronic Acid

No known side effects exist, and clinical trials have shown that negative reactions are rare. Since hyaluronic acid occurs naturally in the body, taking small amounts should be of no health concern. However, since hyaluronic acid as a dietary supplement is a relatively new introduction, side effects are not fully known. As always, it is advisable to check with a doctor before deciding to take HA or any other type of supplement.

Suggested Use of Hyaluronic Acid

The suggested serving size is 100 milligrams twice per day. For measurement of this product use an accurate milligram weight scale. Consult the bulk density volumetric table below only if you have calibrated measuring spoons. You can see the full bulk density/volumetric conversion chart for Hyaluronic Acid here.

Bioavailability, Mixing and Solubility of Hyaluronic Acid

Hyaluronic 1% Solution Preparation: To prepare 12 fluid ounces of 1% (by weight) Hyaluronic Acid solution, be aware it should only be dissolved in cold water. Never attempt to dissolve Hyaluronic Acid in hot or room temperature water. You will need the following items:

• 3.56 grams Hyaluronic Acid Powder.
  
• 12 fluid ounces cold distilled water.
  
• 16 fluid ounce or larger capacity wide mouth glass or plastic water bottle with a tightly sealing lid.
  
• Gram weight measuring scale with an accuracy of 0.01 gram and a capacity of 100 grams such as you see on our website listed under the Scales Digital Gram Weight product category.
  
• Pint sized glass or plastic measuring cup.
  
• Thermometer

Directions: 1. Measure out 12 fluid ounces distilled water and pour into water bottle. 2. Place in refrigerator for about 4 hours. 3. Measure the temperature of water to confirm water temperature is 39°F (4°C) or less. 4. Measure 3.56 grams Hyaluronic Acid powder (approximately two level teaspoons). 5. Add the Hyaluronic Acid powder into the water bottle on top of the cold water. 6. Seal the bottle lid tightly and shake the bottle a few times. The Hyaluronic Acid powder will not appear to dissolve but will clump together in floating white masses. This is normal. 7. Place the water bottle with the Hyaluronic Acid powder and cold water into the refrigerator (but do not freeze). 8. Periodically, about every two to four hours, shake the bottle and then place immediately back into refrigerator. After 4 to 8 hours you will notice that the Hyaluronic Acid clumps are turning clear and dispersing into solution. After 12 to 24 hours the Hyaluronic Acid will be completely dissolved forming a thickened and gelatinous liquid with a viscosity between maple syrup and honey, but still pourable. Yield: For internal use a level tablespoon will net approximately 150 milligrams Hyaluronic Acid.

Hyaluronic Acid solution storage: You can store your 1% Hyaluronic Solution in the refrigerator and use it as needed. This HA solution if prepared and stored properly should keep for a minimum of 48 to 72 hours with refrigeration. You should not attempt to store your HA solution at room temperature without the addition of preservatives. The maximum safe time you can keep your HA solution refrigerated without spoilage will depend upon your ability to keep the solution sterile. Microbial contamination of your solution will cause it to spoil and lose its thickness (viscosity). If over time the solution becomes thin or loses its thickness and viscosity it has spoiled and should be discarded.

Adding preservatives to your Hyaluronic Acid solution: To store this HA solution refrigerated for periods of time longer than 3 days you should start this recipe by first adding preservatives to the distilled water. Two such preservatives we inventory are Ascorbic Acid (Vitamin C) and DMAE Bitartrate. Add and dissolve approximately 6 grams Ascorbic Acid and 3 grams DMAE Bitartrate to 12 fluid ounces distilled water at room temperature. After both powders are completely disolved chill the 12 fluid ounces to 39°F (4°C) and then follow the recipe directions above. When taken orally this preserved HA solution will net the following nutritional supplements per level tablespoon: Hyaluronic Acid 150mg, Ascorbic Acid 250mg, DMAE Bitartrate 125mg.

Internal Use: Hyaluronic Acid can be taken internally to support joint and connective tissue health. Hyaluronic Acid powder can be placed directly into the mouth and swallowed with water, or you can mix your dose in food or juice and consume. But for optimal results and bioavailability take a measured amount of a prepared 1% Hyaluronic Acid solution. See above for methods of preparing a 1% Hyaluronic Acid Solution which will approximate 150 milligrams Hyaluronic Acid per 1 level tablespoon of 1% solution.

Topical Use: Hyaluronic Acid can also be applied topically to the skin as a moisturizing agent. Topical use is usually recommended in concentrations between 1/2% but not to exceed 1%. Since Hyaluronic Acid is known to absorb between 500 and 1,000 times its weight in water higher concentrations than 1% will jellify and not flow easily. Understand also that many Hyaluronic Acid Solution sellers will make claims such that their product is a 50% or even a 100% Hyaluronic Acid Solution without disclosing to you that standard industry terminology equates a 100% Hyaluronic Acid Solution as a solution of 99% water and 1% Hyaluronic Acid by weight since this is the concentration that is considered maximal for an Hyaluronic Acid solution to maintain its fluid characteristics.

References & Further Research

WebMD Hyaluronic Acid

Wikipedia, Hyaluronic Acid

Medline Plus Articles on Hyaluronic Acid

NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-label­ing standards and health claim limits. To learn more about DSHEA, visit the FDA Web site.