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What is Creatine Ethyl Ester HCL (CEE)?

Creatine ethyl ester works in the body as a form of potential energy. This dietary supplement -- also known as CEE -- is creatine bonded to an ester, allowing easier access to cell membranes. Because of better absorption rates, lower serving sizes of the supplement are needed.

Athletes working to increase sports performance find creatine a useful tool. A review of clinical studies has found a preponderance of scientific evidence indicating creatine supplementation is effective for a variety of exercise tasks.

Creatine ethyl ester (CEE) supports athletic performance and muscle development in strength sports like powerlifting, weightlifting, and bodybuilding without the unwanted effects of conventional creatine monohydrate.

Creatine is manufactured in the liver by methylation of guanidoacetate using S-adenosyl methionine (SAM) as the methyl donor. Creatine may also be derived from dietary sources, primarily from meat or fish, which contain approximately 4 to 5 grams of creatine per kilogram. Following its biosynthesis, creatine is quickly taken to the skeletal muscle, heart, brain and other tissues. Most of the creatine is metabolized in these tissues into phosphocreatine (creatine phosphate), which is a primary energy storage form in the body.

Creatine increases the availability of ATP, adenosine triphosphate, by donating a phosphate ion. When energy demand is high, creatine phosphate helps ADP (adenosine diphosphate) produce ATP, which drives muscle contraction and protein production. This reaction is reversible. The phosphate of ATP can be transferred back to creatine, generating creatine phosphate by the action of creatine phosphokinase. Phosphocreatine is then stored in the muscle for later energy use. When needed, phosphocreatine later binds with ADP to convert it back to ATP.

Creatine has grown in popularity in recent years. Creatine's influence on ATP is crucial for metabolic activities, especially high performance sports such as weightlifting, sprinting and jumping. Although creatine monohydrate is one of the best supplements available, some people have difficulty with its absorption in the intestines. Creatine ethyl ester addresses this by adding the ester group, resulting in easier absorption and preventing gastrointestinal problems. Owing to its greater solubility in lipids and subsequent better absorption rates, CEE provides faster results even in smaller doses compared to creatine monohydrate.
PureBulk also sells Creatine Ester Malate, dicreatine malate and Creatine Gluconate.

Health Benefits of Creatine Ethyl Ester

Studies have shown that creatine ethyl ester, when supplemented with proper diet, exercise and adequate hydration, may boost exercise performance.

Creatine is an excellent antioxidant. CEE is a uniquely designed to maximize creatine uptake and does not have to be taken with high glycemic carbohydrate sports drinks, because the insulin spike needed with creatine monohydrate is not required of CEE.

Potential side effects from Creatine Ethyl Ester HCL CEE Powder

Creatine can have adverse effects when used in excess. Side effects can include weight gain, anxiety, breathing difficulty, diarrhea, fatigue, fever, headache, kidney problems, nausea, vomiting, rash and stomach upset.

Certain drugs, including diabetes medications, acetaminophen, and diuretics, can have negative interactions with creatine. Taking the stimulants caffeine or ephedra with creatine can increase the risk of side effects. Creatine isn't recommended for people with kidney or liver disease, or diabetes. Others who should avoid taking it are children under age 18 and women who are pregnant or nursing. Don't use creatine if taking any medication or supplement that could affect blood sugar. Drink enough water to prevent dehydration. Let your doctor know before you take creatine or any other supplement.

Purity and Concentration of Creatine Ethyl Ester HCL CEE Powder

This is pure creatine ethyl ester HCL powder, with no additives, fillers or anti-caking agents.

Suggested Use of Creatine Ethyl Ester HCL

The suggested serving size for creatine ethyl ester hydrochloride is 1500 milligrams (3/4 teaspoon) to 3000 milligrams (1.5 teaspoons) before and after workouts, depending on individual needs. Drink plenty of water when using creatine. You can see the full bulk density/volumetric conversion chart for Creatine Ethyl Ester here. Using Alpha Lipoic Acid in conjunction with creatine ethyl ester will increase uptake and absorbency levels.

Bioavailability, Mixing, and Solubility of Creatine Ethyl Ester HCL

To perform its work in cell volumization of the muscle and to make the muscle larger and firmer, creatine needs water. Drink at least a full 8-ounce glass of water eight times a day.

To get the most out of CEE, use creatine before and after a workout with pre- and post-workout meals. On rest days, take only one serving of creatine with a meal.

CEE can be taken with most beverages but do not use caffeine while on creatine. Caffeine reduces the effects of the creatine intake because caffeine is a diuretic. Creatine makes muscles hold water. Caffeine does the opposite, neutralizing the benefits of CEE intake.

Creatine does not have to dissolved to be effective. Taking it with warm water will allow the full benefits of CEE.

How Does Pure Creatine Ethyl Ester HCL Taste?

Pure creatine ethyl ester powder tastes bitter. Mask the taste by mixing creatine into a sour-tasting drink, like lemonade.

References & Further Research

University of Maryland Medical Center: Creatine

Seven Week CEE Supplementation Regimen Study

Potential Therapeutic Uses of Creatine


WebMD: An Overview of Creatine Supplements

NOTE: The Food and Drug Administration has not evaluated these statemnts. This product is not intended to diagnose, treat, cure or prevent any disease.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the federal Dietary Supplement Health and Education Act (DSHEA), which defines dietary supplements and sets product-label­ing standards and health claim limits. To learn more about DSHEA, visit the FDA Web site.